Pesticide use in agriculture and chronic health conditions: A survey-based cross-sectional study in Nepal
Abstract
The long-term (mis)use of chemical pesticides in agriculture may cause chronic health conditions. The study aimed to assess the relationship between pesticide use in agriculture and chronic health conditions of farmers. The study was done in two adjoining villages in Kavrepalanchok district of Nepal: Mahadevsthan having high application rates and long history of the use of pesticides in the agriculture; and Nayagaun - relatively low rates and a short history of the use of pesticides. Data was collected through household surveys, key informant interviews, focus group discussions, ‘door-to-door’ physical health examination, and free medical health camps. We performed an independent sample t-test and Poisson regression in data analysis. The findings showed higher prevalence rates of chronic health conditions in Mahadevsthan compared to Nayagaun. We also observed a significant positive association between pesticide use history and chronic health conditions. The incidence rate for multiple chronic conditions increased by a factor of 1.296 for an additional year of pesticide use. We, however, recommend in-depth longitudinal cohort studies for further examination of the relationship.
Keywords:
Chronic health conditions, Nepal, Pesticide use, Poison regressionDownloads
References
Acquavella, J., Doe, J., Tomenson, J., Chester, G., Cowell, J. and Bloemen, L. (2003). Epidemiologic studies of occupational pesticide exposure and cancer: Regulatory risk assessments and biologic plausibility. Annals of Epidemiology, 13(1): 1–7, https://doi.org/10.1016/S1047-2797(02)00423-4
Aktar, M.W., Sengupta, D. and Chowdhury, A. (2009). Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary toxicology, 2(1): 1–12, https://doi.org/10.2478/v10102-009-0001-7
Alavanja, M.C.R. and Bonner, M.R. (2012). Occupational pesticide exposures and cancer risk: A review. Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 15(4): 238–263, https://doi.org/10.1080/10937404.2012.632358
Alavanja, M.C.R.R., Hoppin, J.A. and Kamel, F. (2004). Health effects of chronic pesticide exposure: cancer and neurotoxicity. Annual Review of Public Health, 25(1): 155–197, https://doi.org/10.1146/annurev.publhealth.25.101802.123020
Allen, L.N., Smith, R.W., Simmons-Jones, F., Roberts, N., Honney, R. and Currie, J. (2020). Addressing social determinants of noncommunicable diseases in primary care: a scoping review. European Journal of Public Health, 30(Supplement_5): 754–765, https://doi.org/10.1093/eurpub/ckaa165.1131
Aryal, K.K., Mehata, S., Neupane, S., Vaidya, A., Dhimal, M., Dhakal, P., Rana, S., Bhusal, C.L., Lohani, G.R., Paulin, F.H., Garg, R.M., Guthold, R., Cowan, M., Riley, L.M. and Karki, K.B. (2015). The burden and determinants of noncommunicable diseases risk factors in Nepal: Findings from a nationwide STEPS survey. PLoS ONE, 10(8): 1–18, https://doi.org/10.1371/journal.pone.0134834
Atreya, K. (2007a). Pesticide Use in Nepal: Understanding Health Costs from Short-term Exposure. Sandee Work. Pap. No. 28-07. Sandee Working Paper No. 28-07Sandee Working Paper No. 28-07 28. Kathmandu, Nepal,
Atreya, K. (2007b). Pesticide use knowledge and practices: A gender differences in Nepal. Environmental Research, 104(2): 305–311, https://doi.org/10.1016/j.envres.2007.01.001
Atreya, K. (2008a). Health costs from short-term exposure to pesticides in Nepal. Social Science & Medicine, 67(4): 511–519, https://doi.org/10.1016/j.socscimed.2008.04.005
Atreya, K. (2008b). Probabilistic assessment of acute health symptoms related to pesticide use under intensified Nepalese agriculture. International Journal of Environmental Health Research, 18(3): 187–208, https://doi.org/10.1080/09603120701694083
Atreya, K. and Sitaula, B.K. (2011). Mancozeb: growing risk for agricultural communities? Himalayan Journal of Sciences, 6(8): 9–10, https://doi.org/10.3126/hjs.v6i8.1794
Atreya, K., Johnsen, F.H. and Sitaula, B.K. (2012). Health and environmental costs of pesticide use in vegetable farming in Nepal. Environment, Development and Sustainability 14(4): 477–493, https://doi.org/10.1007/s10668-011-9334-4
Atreya, K., Sitaula, B.K., Overgaard, H., Bajracharya, R.M. and Sharma, S. (2012). Knowledge, attitude and practices of pesticide use and acetylcholinesterase depression among farm workers in Nepal. International Journal of Environmental Health Research, 22(5): 401–415, https://doi.org/10.1080/09603123.2011.650154
Bhandari, G., Atreya, K., Yang, X., Fan, L. and Geissen, V. (2018). Factors affecting pesticide safety behaviour: The perceptions of Nepalese farmers and retailers. Science of the Total Environment, 631–632: 1560–1571, https://doi.org/10.1016/j.scitotenv.2018.03.144
Bhandari, G.P., Angdembe, M.R., Dhimal, M., Neupane, S. and Bhusal, C. (2014). State of non-communicable diseases in Nepal. BMC Public Health, 14(1): 23, https://doi.org/10.1186/1471-2458-14-23
Brown, S. and Kennedy, G. (2005). A case study of cash cropping in Nepal: Poverty alleviation or inequity? Agriculture and Human Values, 22(1): 105–116, https://doi.org/10.1007/s10460-004-7234-z
Carter, W.S. (2010). Introducing Occupational Health in an Emerging Economy: A Nepal Experience. Annals of Occupational Hygiene, 54(5): 477–485, https://doi.org/10.1093/annhyg/meq036
Cooper, J. and Dobson, H. (2007). The benefits of pesticides to mankind and the environment. Crop Protection, 26: 1337–1348, https://doi.org/10.1016/j.cropro.2007.03.022
Corsini, E., Birindelli, S., Fustinoni, S., De Paschale, G., Mammone, T., Visentin, S., Galli, C.L., Marinovich, M. and Colosio, C. (2005). Immunomodulatory effects of the fungicide Mancozeb in agricultural workers. Toxicology and Applied Pharmacology, 208(2): 178–185, https://doi.org/10.1016/j.taap.2005.02.011
Dahal, B.M., Nyborg, I., Sitaula, B.K. and Bajracharya, R.M. (2009). Agricultural intensification: Food insecurity to income security in a mid-hill watershed of Nepal. International Journal of Agricultural Sustainability, 7(4): 249–260, https://doi.org/10.3763/ijas.2009.0436
Dahal, B.M., Sitaula, B.K., Sharma, S. and Bajracharya, R.M. (2007). Effects of agricultural intensification on the quality of rivers in rural watersheds of Nepal. Journal of Food, Agriculture and Environment, 5(1): 341–347.
Ecobichon, D.J. (2001). Pesticide use in developing countries. Toxicology 160(1): 27–33, https://doi.org/10.1016/S0300-483X(00)00452-2
El-Zaemey, S., Fritschi, L. and Heyworth, J. (2013). Occupational pesticide exposure among Yemeni women. Environmental Research, 122: 45–51, https://doi.org/10.1016/j.envres.2012.12.002
Evangelou, E., Ntritsos, G., Chondrogiorgi, M., Kavvoura, F.K., Hernández, A.F., Ntzani, E.E. and Tzoulaki, I. (2016). Exposure to pesticides and diabetes: A systematic review and meta-analysis. Environment International, 91: 60–68, https://doi.org/10.1016/j.envint.2016.02.013
Everett, C.J. and Matheson, E.M. (2010). Biomarkers of pesticide exposure and diabetes in the 1999-2004 National Health and Nutrition Examination Survey. Environment International, 36(4): 398–401, https://doi.org/10.1016/j.envint.2010.02.010
Gangemi, S., Miozzi, E., Teodoro, M., Briguglio, G., De Luca, A., Alibrando, C., Polito, I. and Libra, M. (2016). Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans (Review). Molecular Medicine Reports, 14(5): 4475–4488, https://doi.org/10.3892/mmr.2016.5817
Garcia, A.M. (2003). Pesticide Exposure and Women’s Health. American Journal of Industrial Medicine 44: 584–594, https://doi.org/10.1002/ajim.10256
Ghimire, S., Mishra, S.R., Baral, B.K., Dhimal, M., Callahan, K.E., Bista, B. and Aryal, K.K. (2019). Noncommunicable disease risk factors among older adults aged 60–69 years in Nepal: findings from the STEPS survey 2013. Journal of Human Hypertension, 33(8): 602–612, https://doi.org/10.1038/s41371-019-0161-7
Goldner, W.S., Sandler, D.P., Yu, F., Shostrom, V., Hoppin, J.A., Kamel, F. and Levan, T.D. (2013). Hypothyroidism and Pesticide Use among Male Private Pesticide Applicators in the Agricultural Health Study. Journal of Occupational and Environmental Medicine, 55(10): 1171–1178,
https://doi.org/10.1097/JOM.0b013e31829b290b
Hawkes, C. and Ruel, M.T. (2006). Understanding the links between agriculture and health. In Hawkes, C. and Ruel, M.T. (Eds), Understanding the Links Between Agriculture and Health, p. Brief 1 of 16. Washington DC: International Food Policy Research Institute (IFPRI), https://doi.org/10.2499/2020focus13
Hernández, A.F., Parrón, T. and Alarcón, R. (2011). Pesticides and asthma. Current Opinion in Allergy and Clinical Immunology, 11(2): 90–96, https://doi.org/10.1097/ACI.0b013e3283445939
Hilbe, J.M. (2014). Modeling Count Data. Statistical Science 25 March 2013. New York, USA: Cambridge University Press, https://doi.org/10.1017/CBO9781139236065
Hoppin, J.A., Valcin, M., Henneberger, P.K., Kullman, G.J., Limbach, D.M., London, S.J., Alavanja, M.C.R. and Sandler, D.P. (2007). Pesticide use and chronic bronchitis among farmers in the agricultural health study. American Journal of Industrial Medicine, 50(12): 969–979, https://doi.org/10.1002/ajim.20523
Jaacks, L.M. and Staimez, L.R. (2015). Association of persistent organic pollutants and non-persistent pesticides with diabetes and diabetes-related health outcomes in Asia: A systematic review. Environment International, 76: 57–70, https://doi.org/10.1016/j.envint.2014.12.001
Jha, R.K., Regmi, A.P., Haque, A.K.E., Murty, M.N. and Shyamsundar, P. (2009). Pesticide Productivity and Vegetable Farming in Nepal. Environmental Valuation in South Asia. Kathmandu, Nepal: South Asian Network for Development and Environmental Economics (SANDEE), https://doi.org/10.1017CBO9780511843938.007
Joshi, S.K., Shrestha, S. and Vaidya, S. (2011). Occupational safety and health studies in Nepal. International Journal of Occupational Safety and Health, 1: 19–26.
Kafle, B.K., Pokhrel, B., Shrestha, S., Raut, R. and Dahal, B. M. (2015). Determination of Pesticide Residues in Water and Soil Samples From Ansikhola Watershed, Kavre, Nepal. International Journal of Geology, Earth & Environmental Sciences, 5(2): 119-127.
Khanal, G. and Singh, A. (2016). Patterns of pesticide use and associated factors among the commercial farmers of Chitwan, Nepal. Environmental Health Insights, 10: 1–7, https://doi.org/10.4137/EHI.S40973.TYPE
Kofod, D.H., Jørs, E., Varma, A., Bhatta, S. and Thomsen, J.F. (2016). The use of self-reported symptoms as a proxy for acute organophosphate poisoning after exposure to chlorpyrifos 50% plus cypermethrin 5% among Nepali farmers: a randomized, double-blind, placebo-controlled, crossover study. Environmental Health, 1–10, https://doi.org/10.1186/s12940-016-0205-1
Leemans, M., Couderq, S., Demeneix, B. and Fini, J.B. (2019). Pesticides with potential thyroid hormone-disrupting effects: A review of recent data. Frontiers in Endocrinology 10(December), https://doi.org/10.3389/fendo.2019.00743
Mamane, A., Baldi, I., Tessier, J.F., Raherison, C. and Bouvier, G. (2015). Occupational exposure to pesticides and respiratory health. European Respiratory Review, 24(136): 306–319, https://doi.org/10.1183/16000617.00006014
Sharma, D., Thapa, R.B., Manandhar, H.K., Shrestha, S.M. and Pradhan, S.B. (2012). Use of pesticides in Nepal and impacts on human health and environment. Journal of Agriculture and Environment, 13, 67-74, https://doi.org/10.3126/aej.v13i0.7590
Mancini, F., Van Bruggen, A.H.C., Jiggins, J.L.S., Ambatipudi, A.C. and Murphy, H. (2005). Acute pesticide poisoning among female and male cotton growers in India. International Journal of Occupational and Environmental Health, 11(3): 221–232, https://doi.org/10.1179/107735205800246064
Miranda, J.J., Kinra, S., Casas, J.P., Davey Smith, G. and Ebrahim, S. (2008). Non-communicable diseases in low- and middle-income countries: Context, determinants and health policy. Tropical Medicine and International Health, 13(10): 1225–1234, https://doi.org/10.1111/j.1365-3156.2008.02116.x
Mishra, S.R., Neupane, D., Bhandari, P.M., Khanal, V. and Kallestrup, P. (2015). Burgeoning burden of non-communicable diseases in Nepal: A scoping review. Globalization and Health, 11(1): 32, https://doi.org/10.1186/s12992-015-0119-7
Mostafalou, S. and Abdollahi, M. (2012). The role of environmental pollution of pesticides in human diabetes. International Journal of Pharmacology, 8(2): 139–140, https://doi.org/10.3923/ijp.2012.139.140
Mostafalou, S. and Abdollahi, M. (2013). Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives. Toxicology and Applied Pharmacology, 268(2): 157–177, https://doi.org/10.1016/j.taap.2013.01.025
Murphy, H.H., Sanusi, A., Dilts, R., Djajadisastra, M., Hirschhorn, N., and Yuliatingsih, S. (2004). Health effects of pesticide use among Indonesian women farmers: part I: exposure and acute health effects. Journal of Agromedicine, 9(2): 349–373, https://doi.org/10.1300/J096v06n04_05
Neupane, D. and Kallestrup, P. (2013). Non-communicable diseases in Nepal: challenges and opportunities. Journal of Nepal Health Research Council, 11(2): 225–228.
Neupane, D., Jørs, E. and Brandt, L. (2014). Pesticide use, erythrocyte acetylcholinesterase level and self-reported acute intoxication symptoms among vegetable farmers in Nepal: a cross-sectional study. Environmental Health, 13(1): 98, https://doi.org/10.1186/1476-069X-13-98
Pethig, R. (2004). Agriculture, pesticides and the ecosystem. Agricultural Economics, 31(1): 17–32, https://doi.org/10.1016/j.agecon.2002.10.003
Pimentel, D. (2005). Environmental and economic costs of the application of pesticides primarily in the United States. Environment, Development and Sustainability, 7: 229–252, https://doi.org/10.1007/978-1-4020-8992-3_4
Pluth, T.B., Zanini, L.A.G. and Battisti, I.D.E. (2019). Pesticide exposure and cancer: an integrative literature review. Saúde em Debate, 43(122): 906–924, https://doi.org/10.1590/0103-1104201912220
Poudel, K.C., Jimba, M., Poudel-Tandukar, K. and Wakai, S. (2005). Lack of occupational health research in Nepal. American Journal of Public Health, 95(4): 550.
Rawal, D.S., Rana, N., Shrestha, S. and Sijapati, J. (2012). Assessment of pesticide residues in some vegetables grown in Kavrepalanchok and Bhaktapur districts. Nepal Journal of Science and Technology, 13(2): 45–50.
Runkle, J., Flocks, J., Economos, J. and Dunlop, A.L. (2017). A systematic review of Mancozeb as a reproductive and developmental hazard. Environment International, 99: 29–42, https://doi.org/10.1016/j.envint.2016.11.006
Safi, J.M. (2002). Association between chronic exposure to pesticides and recorded cases of human malignancy in Gaza Governorates (1990-1999). Science of the Total Environment, 284(1–3): 75–84, https://doi.org/10.1016/S0048-9697(01)00868-3
Saldana, T.M., Basso, O., Hoppin, J.A., Baird, D.D., Knott, C., Blair, A., Alavanja, M.C.R. and Sandler, D.P. (2007). Pesticide exposure and self-reported gestational diabetes mellitus in the agricultural health study. Diabetes Care 30(3): 529–534, https://doi.org/10.2337/dc06-1832
Sexton, S.E., Lei, Z. and Zilberman, D. (2007). The economics of pesticides and pest control. International Review of Environmental and Resource Economics, 1(3): 271–326, https://doi.org/10.1561/101.00000007
Shrestha, P. and Neupane, F.P. (2002). Socio-economic contexts on pesticide use in Nepal. Landschaftsökologie und Umweltforschung 38: 205–223.
Stallones, L. and Beseler, C. (2002). Pesticide illness, farm practices, and neurological symptoms among farm residents in Colorado. Environmental Research, 90(2): 89–97, https://doi.org/10.1006/enrs.2002.4398
Uri, N.D. (1997). A note on the development and use of pesticides. Science of the Total Environment, 204(1): 57–74, https://doi.org/10.1016/S0048-9697(97)00166-6
Wang, Y. and Wang, J. (2020). Modelling and prediction of global non-communicable diseases. BMC Public Health, 20(1): 1–13, https://doi.org/10.1186/s12889-020-08890-4
Wilson, C. and Tisdell, C. (2001). Why farmers continue to use pesticides despite environmental, health and sustainability costs. Ecological Economics 39(3): 449–462, https://doi.org/10.1016/S0921-8009(01)00238-5
Woldeamanuel, G.G., Mingude, A.B., Yitbarek, G.Y. and Taderegew, M.M. (2020). Chronic respiratory symptoms and pulmonary function status in Ethiopian agricultural workers: A comparative study. BMC Pulmonary Medicine, 20(86): https://doi.org/10.1186/s12890-020-1120-3
World Health Organization (WHO). (2018). Noncommunicable diseases. Fact Sheet. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases (accessed 12 December 2020)
Published
How to Cite
Issue
Section
Copyright (c) 2020 Agriculture and Environmental Science Academy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.